Epidermal growth factor receptor (EGFr) levels were evaluated in paraffin-embedded tumour specimens of non-small cell lung cancer (NSCLC) from 176 patients who underwent surgical resection. The EGFr expression was evaluated by immunocytochemical assay using a monoclonal antibody which recognises the external domain of the receptor. EGFr immunoreactivity was significantly higher in squamous than in non-squamous cell carcinomas (P = 0.0009). Hilar and/or mediastinal nodal involvement was found in 29 of 105 (27.4%) squamous cancers, and in this group of patients, the mean of EGFr positive cells was significantly higher than that of patients without nodal involvement (P = 0.01). No significant correlations were found between the expression of EGFr and other clinicopathological or biological parameters such as T-status, grading, proliferative activity. EGFR is suggested to represent a useful indicator of nodal metastasis in NSCLC.
|Autori:||Fontanini G; Vignati S; Bigini D; Mussi A; Lucchi H; Angeletti CA; Pingitore R; Pepe S; Basolo F; Bevilacqua G. Eur J Cancer. 1995; 31A(2):178-83|
|Titolo:||Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype.|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1016/0959-8049(93)00421-M|
|Appare nelle tipologie:||1.1 Articolo in rivista|