Many patients with chronic hepatitis C virus (HCV) develop type 2 diabetes (1). This prevalence is much higher than that observed in the general population and in patients with other chronic liver diseases such as hepatitis B virus, alcoholic liver disease, and primary biliary cirrhosis. Furthermore, it has been shown that post-transplantation type 2 diabetes appears to be higher among patients with HCV (2). However, the pathogenetic basis for the association between HCV infection and diabetes has not been understood. A direct involvement of the virus in the development of insulin resistance has been proposed, and β-cell dysfunction in HCV-positive patients has been observed in some cases (1). Because HCV can infect many tissues other than the liver (3), we hypothesized that the virus might directly damage insulin-secreting cells. This article suggests that HCV may be present in human pancreatic β-cells and demonstrates that islet cells from HCV-positive patients have morphological and functional defects.

Hepatitis C Virus Infection and Human Pancreatic {beta}-Cell Dysfunction

CAMPANI, DANIELA;BOGGI, UGO;POLLERA, MARIA;DEL PRATO, STEFANO;MOSCA, FRANCO;FILIPPONI, FRANCO;MARCHETTI, PIERO
2005-01-01

Abstract

Many patients with chronic hepatitis C virus (HCV) develop type 2 diabetes (1). This prevalence is much higher than that observed in the general population and in patients with other chronic liver diseases such as hepatitis B virus, alcoholic liver disease, and primary biliary cirrhosis. Furthermore, it has been shown that post-transplantation type 2 diabetes appears to be higher among patients with HCV (2). However, the pathogenetic basis for the association between HCV infection and diabetes has not been understood. A direct involvement of the virus in the development of insulin resistance has been proposed, and β-cell dysfunction in HCV-positive patients has been observed in some cases (1). Because HCV can infect many tissues other than the liver (3), we hypothesized that the virus might directly damage insulin-secreting cells. This article suggests that HCV may be present in human pancreatic β-cells and demonstrates that islet cells from HCV-positive patients have morphological and functional defects.
2005
Masini, M; Campani, Daniela; Boggi, Ugo; Menicagli, M; Funel, N; Pollera, Maria; Lupi, R; DEL GUERRA, S; Bugliani, M; Torri, S; DEL PRATO, Stefano; Mosca, Franco; Filipponi, Franco; Marchetti, Piero
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/179214
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