OBJECTIVE: To evaluate the acute effect of sildenafil and tadalafil on seminal parameters in young, infertile patients. DESIGN: Prospective, randomized, double-blind, crossover clinical investigation on semen parameters after the administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg). SETTING: An academic hospital as well as a male infertility center and clinical andrology laboratories. PATIENT(S): Eighteen young, infertile men. INTERVENTION(S): Oral administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg) in a blind, randomized order. The semen samples were collected 1 or 2 hours after each treatment. MAIN OUTCOME MEASURE(S): Changes in sperm parameters after sildenafil and tadalafil administration, compared with the basal conditions. RESULT(S): A significant increase in sperm progressive motility (median value, 37.0% vs. 28.5%) was observed after sildenafil administration as compared with baseline; in contrast, a significant decreased value was observed after tadalafil (median value, 21.5% vs. 28.5%). CONCLUSION(S): These preliminary results indicate that sperm motility appears to be acutely affected in young, infertile patients by a single dose of sildenafil and tadalafil, with opposite effects: stimulatory by the former and inhibitory by the latter.
Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men
MORELLI, GIROLAMO;CAGLIERESI, CAROLINA;SELLI, CESARE;MACCHIA, ENRICO;MARTINO, ENIO;
2007-01-01
Abstract
OBJECTIVE: To evaluate the acute effect of sildenafil and tadalafil on seminal parameters in young, infertile patients. DESIGN: Prospective, randomized, double-blind, crossover clinical investigation on semen parameters after the administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg). SETTING: An academic hospital as well as a male infertility center and clinical andrology laboratories. PATIENT(S): Eighteen young, infertile men. INTERVENTION(S): Oral administration of a single dose of sildenafil (50 mg) or tadalafil (20 mg) in a blind, randomized order. The semen samples were collected 1 or 2 hours after each treatment. MAIN OUTCOME MEASURE(S): Changes in sperm parameters after sildenafil and tadalafil administration, compared with the basal conditions. RESULT(S): A significant increase in sperm progressive motility (median value, 37.0% vs. 28.5%) was observed after sildenafil administration as compared with baseline; in contrast, a significant decreased value was observed after tadalafil (median value, 21.5% vs. 28.5%). CONCLUSION(S): These preliminary results indicate that sperm motility appears to be acutely affected in young, infertile patients by a single dose of sildenafil and tadalafil, with opposite effects: stimulatory by the former and inhibitory by the latter.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
