The known macrolide pyrenophorol (synonym helmidiol) (1), the new 2,3,10,11-tetrahydropyrenophorol (3), and (4S,7R)- 4,7-dihydroxyoctanoic acid (4), the monomeric acid of the sixteen-membered cyclic diolide 1, were isolated from an endophytic Phoma sp. The relative configuration of tetrahydropyrenophorol (3) was confirmed by X-ray single crystal analysis and its absolute configuration determined by the solid-state TDDFT CD methodology. Compounds 1 and 4 show antifungal activity and the acid 4 is also an algicide.
|Autori interni:||PESCITELLI, GENNARO|
|Autori:||KROHN K; FAROOQ U; FLRKE U; SCHULZ B; DRAEGER S; PESCITELLI G; SALVADORI P; ANTUS S; KURTAN T|
|Titolo:||Secondary Metabolites Isolated from an Endophytic Phoma sp. – Absolute Configuration of Tetrahydropyrenophorol Using the Solid-State TDDFT CD Methodology|
|Anno del prodotto:||2007|
|Digital Object Identifier (DOI):||10.1002/ejoc.200601128|
|Appare nelle tipologie:||1.1 Articolo in rivista|