The synthesis and the antimicrobial properties of a new series of cephalosporinic β-lactam antibiotics is described. The data reported in the present paper show the potential of this type of substituted cephalosporins as new anti Gram-positive antibiotic drags. In fact, all compounds tested showed a good in vitro antibacterial activity against the most relevant Gram- positive pathogens including resistant species that currently represent unmet medical need. On the contrary, the new synthesized compounds were found to be completely devoid of any activity on Gram-negative bacteria up to a concentration of the single agent of 128 μg/ml.
|Autori interni:||MACCHIA, MARCO|
|Autori:||BALSAMO A.; BARONTINI S.; CALVANI F.;Gentili D.; MACCHIA M; ROSSELLO A.;DI MODUGNO E.; FELICI A.|
|Titolo:||New N-Substituted 7-Aminocephalosporanic Acid Derivatives as Potential Agents Against Streptococcus Pneumoniae. Synthesis and In Vitro Activity|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.1016/S0960-894X(99)00127-4|
|Appare nelle tipologie:||1.1 Articolo in rivista|