A variety of chiral 6-hepten-1-ynes have been found to undergo cyclization to titanabicyclopentenes by (eta(2)-propene)Ti(Oi-Pr)(2) with excellent yields and degrees of exo-stereoselectivity depending on the substrate steric requirements. In the framework of a plausible cyclization mechanism several conformational features which can regulate the stereoinduction have been suggested.
Diastereoselectivity in the synthesis of bicyclic titanacyclopentenes from chiral 6-hepten-1-ynes
DI BARI, LORENZO;CAPORUSSO, ANNA MARIA
2000-01-01
Abstract
A variety of chiral 6-hepten-1-ynes have been found to undergo cyclization to titanabicyclopentenes by (eta(2)-propene)Ti(Oi-Pr)(2) with excellent yields and degrees of exo-stereoselectivity depending on the substrate steric requirements. In the framework of a plausible cyclization mechanism several conformational features which can regulate the stereoinduction have been suggested.File in questo prodotto:
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