Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.

Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment.

Greta Alì;Giulia Ricci;Paola Lenzi;Lucia Petrozzi;Gabriele Siciliano
2012

Abstract

Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.
Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/192998
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