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EnglishCapecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.
Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment. / Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele. - In: NEUROMUSCULAR DISORDERS. - ISSN 0960-8966. - (2012), pp. 767-770.
| Autori interni: | ||
| Autori: | Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele | |
| Titolo: | Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment. | |
| Anno del prodotto: | 2012 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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