Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.
Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment. / Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele. - In: NEUROMUSCULAR DISORDERS. - ISSN 0960-8966. - (2012), pp. 767-770.
Autori interni: | |
Autori: | Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele |
Titolo: | Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment. |
Anno del prodotto: | 2012 |
Appare nelle tipologie: | 1.1 Articolo in rivista |