Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.
|Autori:||Orsucci, Daniele; Pizzanelli, Chiara; Ali', Greta; Calabrese, Rosanna; Ricci, Giulia; Lenzi, Paola; Petrozzi, Lucia; Moretti, Policarpo; Siciliano, Gabriele|
|Titolo:||Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment.|
|Anno del prodotto:||2012|
|Appare nelle tipologie:||1.1 Articolo in rivista|