The study aim was to evaluate the effect on globe position and respiration of three dosages of IV rocuronium. Twenty-eight dogs of various breeds, aged 1 (0.4– 10 years) [median (range)], anaesthetized for ophthalmic procedures were enrolled. Dogs were divided into 4 groups of 7 animals (G1–G4). G1, G2, G3 received 0.075 mg kg)1, 0.05 mg kg)1, 0.03 mg kg)1 of IV rocuronium, respectively; G4 (control group) received IV 0.9% NaCl. Dogs were anaesthetized with dexmedetomidine (2.5 lg kg)1), methadone (0.1 mg kg)1), propofol (2 mg kg)1) and isoflurane. Neuromuscular function was assessed with acceleromyography using train of four (ToF) stimulation of the ulnar nerve. Throughout anaesthesia ECG, HR, SAP, DAP, MAP, fR, PE¢CO2, FE¢ISO andV . T were monitored. Alteration in globe position was recorded. No significant differences were found between groups concerning HR, fR, PE¢CO2, FE¢ISO and _V T. Four ToF twitches were seen at all times in all groups. Globe position results are reported in Table 1. All doses of rocuronium produced globe centralization with minimal respiratory effects. The 0.03 mg kg)1 dose could only be useful for very short ophthalmic procedures or prior to IV infusions due to its short duration of effect. Table 1 Times of centralization and maintenance of the globe position Groups Globe centralization time (seconds) Time of maintained globe central position (minutes) G1 38.8 ± 6.6 25.3 ± 3.1 G2 47.6 ± 16.6 26.1 ± 3.8 G3 56.8 ± 24.8* 9.2 ± 3.5§ G4 – – *Significantly different from G1; §Significantly different from G1 and G2.

Effects of Rocuronium Bromide on Globe Position and Respiratory Function in Anaesthetized Dogs: Comparison Between Three Different Dosages

BRIGANTI, ANGELA;BARSOTTI, GIOVANNI;BREGHI, GLORIA
2011

Abstract

The study aim was to evaluate the effect on globe position and respiration of three dosages of IV rocuronium. Twenty-eight dogs of various breeds, aged 1 (0.4– 10 years) [median (range)], anaesthetized for ophthalmic procedures were enrolled. Dogs were divided into 4 groups of 7 animals (G1–G4). G1, G2, G3 received 0.075 mg kg)1, 0.05 mg kg)1, 0.03 mg kg)1 of IV rocuronium, respectively; G4 (control group) received IV 0.9% NaCl. Dogs were anaesthetized with dexmedetomidine (2.5 lg kg)1), methadone (0.1 mg kg)1), propofol (2 mg kg)1) and isoflurane. Neuromuscular function was assessed with acceleromyography using train of four (ToF) stimulation of the ulnar nerve. Throughout anaesthesia ECG, HR, SAP, DAP, MAP, fR, PE¢CO2, FE¢ISO andV . T were monitored. Alteration in globe position was recorded. No significant differences were found between groups concerning HR, fR, PE¢CO2, FE¢ISO and _V T. Four ToF twitches were seen at all times in all groups. Globe position results are reported in Table 1. All doses of rocuronium produced globe centralization with minimal respiratory effects. The 0.03 mg kg)1 dose could only be useful for very short ophthalmic procedures or prior to IV infusions due to its short duration of effect. Table 1 Times of centralization and maintenance of the globe position Groups Globe centralization time (seconds) Time of maintained globe central position (minutes) G1 38.8 ± 6.6 25.3 ± 3.1 G2 47.6 ± 16.6 26.1 ± 3.8 G3 56.8 ± 24.8* 9.2 ± 3.5§ G4 – – *Significantly different from G1; §Significantly different from G1 and G2.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/195961
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact