Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp

Kock, I; Draeger, S; Schulz, B; Elsässer, B; Kurtán, T; Kenéz, A; Antus, S; Pescitelli, Gennaro; Salvadori, Piero; Speakman J., B; Rheinheimer, J; Krohn, K.

doi:10.1002/ejoc.200801083

Two new isochromans named pseudoanguillosporin A (2a) and B (3), together with the known cephalochromin (1), were isolated from Pseudoanguillospora sp. The C-2 absolute configuration of 2a and 3 was deduced from its CD spectrum by the isochroman helicity rule, supported by TDDFT CD calculations. The absolute configuration of the sec-hydroxyl group of 3 was determined by the Mosher NMR method from the MPA esters of its methylated erivative. The axial chirality of 1 was assigned through exciton analysis of its CD spectrum and confirmed by ZINDO CD calculations. The metabolites showed broad antimicrobial activities.

Autori interni:	KOCK I DRAEGER S SCHULZ B ELSÄSSER B KURTÁN T KENÉZ A ANTUS S PESCITELLI, GENNARO SALVADORI, PIERO SPEAKMAN J. B RHEINHEIMER J KROHN K. mostra contributor esterni nascondi contributor esterni
Autori:	KOCK I; DRAEGER S; SCHULZ B; ELSÄSSER B; KURTÁN T; KENÉZ A; ANTUS S; PESCITELLI G; SALVADORI P; SPEAKMAN J-B; RHEINHEIMER J; KROHN K
Titolo:	Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp
Anno del prodotto:	2009
Digital Object Identifier (DOI):	10.1002/ejoc.200801083
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11568/195965

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