EnglishTwo new isochromans named pseudoanguillosporin A (2a) and B (3), together with the known cephalochromin (1), were isolated from Pseudoanguillospora sp. The C-2 absolute configuration of 2a and 3 was deduced from its CD spectrum by the isochroman helicity rule, supported by TDDFT CD calculations. The absolute configuration of the sec-hydroxyl group of 3 was determined by the Mosher NMR method from the MPA esters of its methylated erivative. The axial chirality of 1 was assigned through exciton analysis of its CD spectrum and confirmed by ZINDO CD calculations. The metabolites showed broad antimicrobial activities.
| Autori: | |
| Autori: | KOCK I; DRAEGER S; SCHULZ B; ELSÄSSER B; KURTÁN T; KENÉZ A; ANTUS S; PESCITELLI G; SALVADORI P; SPEAKMAN J-B; RHEINHEIMER J; KROHN K |
| Titolo: | Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp |
| Anno del prodotto: | 2009 |
| Digital Object Identifier (DOI): | 10.1002/ejoc.200801083 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/11568/195965
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