Two new isochromans named pseudoanguillosporin A (2a) and B (3), together with the known cephalochromin (1), were isolated from Pseudoanguillospora sp. The C-2 absolute configuration of 2a and 3 was deduced from its CD spectrum by the isochroman helicity rule, supported by TDDFT CD calculations. The absolute configuration of the sec-hydroxyl group of 3 was determined by the Mosher NMR method from the MPA esters of its methylated erivative. The axial chirality of 1 was assigned through exciton analysis of its CD spectrum and confirmed by ZINDO CD calculations. The metabolites showed broad antimicrobial activities.
|Autori:||KOCK I; DRAEGER S; SCHULZ B; ELSÄSSER B; KURTÁN T; KENÉZ A; ANTUS S; PESCITELLI G; SALVADORI P; SPEAKMAN J-B; RHEINHEIMER J; KROHN K|
|Titolo:||Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus Pseudoanguillospora sp|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1002/ejoc.200801083|
|Appare nelle tipologie:||1.1 Articolo in rivista|