The new bicyclic fusidilactones D (1) and E (2), along with the known and related fusidilactone B (3), have been isolated from the fungal endophyte Fusidium sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis and the relative configurations were confirmed by an X-ray diffraction study of a single crystal of 3. The absolute configurations were determined by TDDFT calculations of CD spectra using the solid-state CD/TDDFT approach. The metabolites exhibited moderate antifungal, antibacterial, and antialgal activities.
|Autori:||QIN SONG; KROHN KARSTEN; FLÖRKE ULRICH; SCHULZ BARBARA; DRAEGER SIEGFRIED; PESCITELLI GENNARO; SALVADORI P; ANTUS SANDOR; KURTÁN TIBOR|
|Titolo:||Two New Fusidilactones from the Fungal Endophyte Fusidium sp|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1002/ejoc.200900152|
|Appare nelle tipologie:||1.1 Articolo in rivista|