The new bicyclic fusidilactones D (1) and E (2), along with the known and related fusidilactone B (3), have been isolated from the fungal endophyte Fusidium sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis and the relative configurations were confirmed by an X-ray diffraction study of a single crystal of 3. The absolute configurations were determined by TDDFT calculations of CD spectra using the solid-state CD/TDDFT approach. The metabolites exhibited moderate antifungal, antibacterial, and antialgal activities.
Two New Fusidilactones from the Fungal Endophyte Fusidium sp
PESCITELLI, GENNARO;SALVADORI, PIERO;
2009-01-01
Abstract
The new bicyclic fusidilactones D (1) and E (2), along with the known and related fusidilactone B (3), have been isolated from the fungal endophyte Fusidium sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis and the relative configurations were confirmed by an X-ray diffraction study of a single crystal of 3. The absolute configurations were determined by TDDFT calculations of CD spectra using the solid-state CD/TDDFT approach. The metabolites exhibited moderate antifungal, antibacterial, and antialgal activities.File in questo prodotto:
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