As a matter of FACT! Carbazoles known as curaxins effectively bind the heterodimeric protein complex, FACT, the sequestration of which causes promotion of multiple pathways (p53 activation and NF-κB inhibition) leading to tumor cell death, without inducing DNA damage. Given these results, curaxins hold promise for the development of effective anticancer therapies with decreased toxicity.
Curaxins: A New Family of Non-genotoxic Multitargeted Anticancer Agents
DI BUSSOLO, VALERIA;MINUTOLO, FILIPPO
2011-01-01
Abstract
As a matter of FACT! Carbazoles known as curaxins effectively bind the heterodimeric protein complex, FACT, the sequestration of which causes promotion of multiple pathways (p53 activation and NF-κB inhibition) leading to tumor cell death, without inducing DNA damage. Given these results, curaxins hold promise for the development of effective anticancer therapies with decreased toxicity.File in questo prodotto:
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