As a matter of FACT! Carbazoles known as curaxins effectively bind the heterodimeric protein complex, FACT, the sequestration of which causes promotion of multiple pathways (p53 activation and NF-κB inhibition) leading to tumor cell death, without inducing DNA damage. Given these results, curaxins hold promise for the development of effective anticancer therapies with decreased toxicity.

Curaxins: A New Family of Non-genotoxic Multitargeted Anticancer Agents

DI BUSSOLO, VALERIA;MINUTOLO, FILIPPO
2011

Abstract

As a matter of FACT! Carbazoles known as curaxins effectively bind the heterodimeric protein complex, FACT, the sequestration of which causes promotion of multiple pathways (p53 activation and NF-κB inhibition) leading to tumor cell death, without inducing DNA damage. Given these results, curaxins hold promise for the development of effective anticancer therapies with decreased toxicity.
DI BUSSOLO, Valeria; Minutolo, Filippo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/197522
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