A series of l-@-nitrophenyl)-2-aminoethanold erivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl- substituted compounds. In agreement with the previously obtained results, the weak a-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of a-adrenergic drugs.
Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines
CROTTI, PAOLO;LAPUCCI, ANNALINA;
1979-01-01
Abstract
A series of l-@-nitrophenyl)-2-aminoethanold erivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl- substituted compounds. In agreement with the previously obtained results, the weak a-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of a-adrenergic drugs.File in questo prodotto:
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