A series of l-@-nitrophenyl)-2-aminoethanold erivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl- substituted compounds. In agreement with the previously obtained results, the weak a-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of a-adrenergic drugs.
|Autori:||BALSAMO A; CROTTI P; LAPUCCI A; MACCHIA B; MACCHIA F; DELTACCA M; MAZZANTI L; CESERANI R|
|Titolo:||Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines|
|Anno del prodotto:||1979|
|Digital Object Identifier (DOI):||10.1021/jm00192a023|
|Appare nelle tipologie:||1.1 Articolo in rivista|