Cyclophosphamide (CP)-induced micronuclei were evaluated in females of two strains of mice (C57BL and CDl), in F1 hybrid females and in fetuses (day 13 of gestation) obtained from different crosses. F 1 adult hybrids from a cross between the strain with a high level of induced micronuclei (C57BL) and the strain with a low response (CDl) exhibited micronuclei values closer to the latter. CDl/CDl fetuses showed a higher susceptibility than C57BL/C57BL ones. Heterozygous fetuses from reciproca! crosses, whatever the maternal genotype, showed the same sensitivity, which is very dose to that of C57BL/C57BL fetuses. Phenobarbital (PB) pre-treatment modified the mutagenic response to CP depending on the genotype of the treated animai. These results demonstrate that the response to a pro-mutagen requiring metabolic activation depends to a large extent on the genetic background ofthe target animals, and that mother-fetus interactions in transplacental mutagenesis seem to depend more on the fetal than on the maternal genotype.
|Autori:||Barale R; Migliore L; Zucconi D; Ciranni R; Casini D; Carducci A; Loprieno N|
|Titolo:||Experimental model for evaluating the effects of genetic and exogenous factors on transplacental mutagenesis|
|Anno del prodotto:||1987|
|Appare nelle tipologie:||1.1 Articolo in rivista|