Liquid holding (LH) recovery was matched with three-way differential staining (TWD) to assess the reduction of damage induced in DNA following treatment with 4-nitroquinoline-1-oxide (4NQO) in resting (GO) lymphocytes. Human peripheral lymphocytes (HPL) from three donors were used to evaluate lesion persistence and individual repair capacity. Our data are in contrast to those for diepoxybutane (Ponzanelli et al., 1995) and suggest that LH recovery is completely inefficient in removing 4NQO induced lesions, which are only partially repaired after one cell cycle.
|Autori:||Ponzanelli I; Landi S; Barale R|
|Titolo:||Persistence of 4-nitroquinoline-1-oxide induced lesions in human lymphocytes|
|Anno del prodotto:||1996|
|Digital Object Identifier (DOI):||10.1016/0921-8777(95)00051-8|
|Appare nelle tipologie:||1.1 Articolo in rivista|