Highly efficient NMR enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of sevoflurane, by heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin

Uccello Barretta, Gloria; Sicoli, G.; Balzano, Federica; Schurig, V.; Salvadori, Piero

doi:10.1016/j.tetasy.2006.09.019

The molecular basis of the efficient enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of the inhalation anaesthetic sevoflurane, using heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin as chiral selector, has been investigated by NMR spectroscopy. An interaction mechanism is proposed, which highlights the role of the functional groups on the b-cyclodextrin rims in addition to a partial molecular inclusion.

Autori interni:	UCCELLO BARRETTA, GLORIA SICOLI G. BALZANO, FEDERICA SCHURIG V. SALVADORI, PIERO mostra contributor esterni nascondi contributor esterni
Autori:	UCCELLO-BARRETTA G.; SICOLI G.; BALZANO F.; SCHURIG V.; SALVADORI P.
Titolo:	Highly efficient NMR enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of sevoflurane, by heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin
Anno del prodotto:	2006
Digital Object Identifier (DOI):	10.1016/j.tetasy.2006.09.019
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11568/199189

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