The molecular basis of the efficient enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of the inhalation anaesthetic sevoflurane, using heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin as chiral selector, has been investigated by NMR spectroscopy. An interaction mechanism is proposed, which highlights the role of the functional groups on the b-cyclodextrin rims in addition to a partial molecular inclusion.
Autori interni: | |
Autori: | UCCELLO-BARRETTA G.; SICOLI G.; BALZANO F.; SCHURIG V.; SALVADORI P. |
Titolo: | Highly efficient NMR enantiodiscrimination of 1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane, a chiral degradation product of sevoflurane, by heptakis(2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-b-cyclodextrin |
Anno del prodotto: | 2006 |
Digital Object Identifier (DOI): | 10.1016/j.tetasy.2006.09.019 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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