The preparation of a chiral phosphoramidite ligand anchored to a Merrifield resin has been studied and its use in the copper-catalysed heterogeneous enantioselective conjugate addition of ZnEt2 to 2-cyclohexenone investigated. The insoluble polymer bound ligand could be recovered quantitatively by filtration, affording e.e. values in the range 65–84% in the course of successive recycle runs.
An insoluble polymer-bound phosphoramidite for the copper-catalysed enantioselective 1,4-addition of ZnEt2 to 2-cyclohexenone
MANDOLI, ALESSANDRO;SALVADORI, PIERO
2003-01-01
Abstract
The preparation of a chiral phosphoramidite ligand anchored to a Merrifield resin has been studied and its use in the copper-catalysed heterogeneous enantioselective conjugate addition of ZnEt2 to 2-cyclohexenone investigated. The insoluble polymer bound ligand could be recovered quantitatively by filtration, affording e.e. values in the range 65–84% in the course of successive recycle runs.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
