The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.

IMPROVING THE SOLUBILITY OF A NEW CLASS OF ANTIINFLAMMATORY PHARMACODYNAMIC HYBRIDS, THAT RELEASE NITRIC OXIDE AND INHIBIT CYCLOXYGENASE-2 ISOENZYME

CALDERONE, VINCENZO;MARTELLI, ALMA;TESTAI, LARA;
2012

Abstract

The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
Biava, M; Battilocchio, C; Poce, G; Alfonso, S; Consalvi, S; Porretta, Gc; Schenone, S; Calderone, Vincenzo; Martelli, Alma; Testai, Lara; Ghelardini, C; DI CESARE MANNELLI, L; Sautebin, L; Rossi, A; Giordani, A; Patrognani, P; Anzini, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/200169
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