The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
IMPROVING THE SOLUBILITY OF A NEW CLASS OF ANTIINFLAMMATORY PHARMACODYNAMIC HYBRIDS, THAT RELEASE NITRIC OXIDE AND INHIBIT CYCLOXYGENASE-2 ISOENZYME
CALDERONE, VINCENZO;MARTELLI, ALMA;TESTAI, LARA;
2012-01-01
Abstract
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.File in questo prodotto:
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