Two metabolites, the known antitumor macrolide hypothemycin 1 and its new 5'-O-methyl ether, 5'-O-methylhypothemycin 2, and the known steroid ergosterol 3, were isolated from a Phoma sp. The structures were elucidated by means of spectroscopic data analysis, and the absolute configuration of hypothemycin 1 was confirmed by single crystal X-ray analysis in combination with the new solid-state CD/TDDFT methodology. Since the solid-state CD spectrum shows contributions from intermolecular interactions in the crystal, 1 represents a critical test case for our solid-state CD/TDDFT approach.

Absolute configuration of hypothemycin and 5'-O-methylhypothemycin from Phoma sp.—a test case for solid state CD/TDDFT approach

PESCITELLI, GENNARO;SALVADORI, PIERO;
2007

Abstract

Two metabolites, the known antitumor macrolide hypothemycin 1 and its new 5'-O-methyl ether, 5'-O-methylhypothemycin 2, and the known steroid ergosterol 3, were isolated from a Phoma sp. The structures were elucidated by means of spectroscopic data analysis, and the absolute configuration of hypothemycin 1 was confirmed by single crystal X-ray analysis in combination with the new solid-state CD/TDDFT methodology. Since the solid-state CD spectrum shows contributions from intermolecular interactions in the crystal, 1 represents a critical test case for our solid-state CD/TDDFT approach.
Hussain, H; Krohn, K; Floerke, U; Schulz, B; Draeger, S; Pescitelli, Gennaro; Salvadori, Piero; Antus, S; Kurtan, T.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/201246
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