Two metabolites, the known antitumor macrolide hypothemycin 1 and its new 5'-O-methyl ether, 5'-O-methylhypothemycin 2, and the known steroid ergosterol 3, were isolated from a Phoma sp. The structures were elucidated by means of spectroscopic data analysis, and the absolute configuration of hypothemycin 1 was confirmed by single crystal X-ray analysis in combination with the new solid-state CD/TDDFT methodology. Since the solid-state CD spectrum shows contributions from intermolecular interactions in the crystal, 1 represents a critical test case for our solid-state CD/TDDFT approach.
|Autori:||HUSSAIN H; KROHN K; FLOERKE U; SCHULZ B; DRAEGER S; PESCITELLI G; SALVADORI P; ANTUS S; KURTAN T|
|Titolo:||Absolute configuration of hypothemycin and 5'-O-methylhypothemycin from Phoma sp.—a test case for solid state CD/TDDFT approach|
|Anno del prodotto:||2007|
|Digital Object Identifier (DOI):||10.1016/j.tetasy.2007.04.005|
|Appare nelle tipologie:||1.1 Articolo in rivista|