Some 1-[4-(9-benzyl-2-phenyl-9H-purin-6-ylamino)-phenyl]-3-phenyl-urea derivatives and some 1-[4-(9-benzyl-2-phenyl-9H-8-azapurin-6-ylamino)-phenyl]-3-phenyl-urea derivatives were synthesised and evaluated for their interaction with adenosine receptors. It was found that some of these compounds can act as positive enhancers of agonist and antagonist radioligands for the A(2A) adenosine receptors. This evidence was also strengthened by functional data. Other compounds can act as negative modulators. Furthermore these compounds show inhibitory properties for A(1) and A(3) adenosine receptors.

N(6)-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and biological evaluation as allosteric modulators of A(2A) adenosine receptors

GIORGI, IRENE;BIANUCCI, ANNA MARIA PAOLA;BORGHINI, ALICE;PIETRA, DANIELE;CALDERONE, VINCENZO;MARTELLI, ALMA
2008

Abstract

Some 1-[4-(9-benzyl-2-phenyl-9H-purin-6-ylamino)-phenyl]-3-phenyl-urea derivatives and some 1-[4-(9-benzyl-2-phenyl-9H-8-azapurin-6-ylamino)-phenyl]-3-phenyl-urea derivatives were synthesised and evaluated for their interaction with adenosine receptors. It was found that some of these compounds can act as positive enhancers of agonist and antagonist radioligands for the A(2A) adenosine receptors. This evidence was also strengthened by functional data. Other compounds can act as negative modulators. Furthermore these compounds show inhibitory properties for A(1) and A(3) adenosine receptors.
Giorgi, Irene; Biagi, G; Bianucci, ANNA MARIA PAOLA; Borghini, Alice; Livi, O; Leonardi, M; Pietra, Daniele; Calderone, Vincenzo; Martelli, Alma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/201407
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