The 3-1 (2-ethoxyphenoxy)methyl]piperidine derivatives 3-5 were synthesized and screened as potential antidepressant agents by the reserpine interaction test in mice and the evaluation of reuptake inhibition of biogenic amines in pig brain synaptosomal fractions. In addition, their anticonvulsant activity, tested by pentylenetetrazole antagonism, and approximate acute toxicity were evaluated. In vivo and in vitro tests showed that compounds 3 and 5 possess a biological activity comparable to that of the antidepressant drug viloxazine (2).
|Autori:||BALSAMO A; GIORGI I; LAPUCCI A; LUCACCHINI A; MACCHIA B; MACCHIA F; MARTIN C; ROSSI A|
|Titolo:||3-[(2-Ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity|
|Anno del prodotto:||1987|
|Digital Object Identifier (DOI):||10.1021/jm00384a040|
|Appare nelle tipologie:||1.1 Articolo in rivista|