By means of several proton and C-13 relaxation experimental techniques, selected internuclear distances and the rotational correlation time for 1-(aminomethyl)-5,6-dihydroxyisochroman hydrobromide were determined. The molecule dissolved in DMSO-d(6) does not show relevant internal motions and is found to tumble isotropically. Two different procedures for determining the cross-relaxation rates, one using mono- and biselective relaxation rates and the other following the build-up of the transient NOE, are compared, The two methods are formally equivalent, but have different advantages and drawbacks while yielding essentially the same structural picture.
|Autori interni:||DI BARI, LORENZO|
UCCELLO BARRETTA, GLORIA
|Autori:||DI BARI L.; UCCELLO BARRETTA G; MANERA C.|
|Titolo:||Stereochemistry and dynamics of the hydrobromide of 1-(aminomethyl)-5,6-dihydroxyisochroman, semirigid analogue of catecholamines|
|Anno del prodotto:||1996|
|Appare nelle tipologie:||1.1 Articolo in rivista|