Some β-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (>C=NOCH2) could be a "bioisoster" of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison.

Synthesis and antimicrobial properties of substituted ß-aminoxypropionyl penicillins and cephalosporins

LAPUCCI, ANNALINA;ORLANDINI, ELISABETTA;ROSSELLO, ARMANDO
1989

Abstract

Some β-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (>C=NOCH2) could be a "bioisoster" of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison.
A., Balsamo; G., Broccali; Lapucci, Annalina; B., Macchia; F., Macchia; Orlandini, Elisabetta; Rossello, Armando
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/204159
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