A reversed-phase HPLC method has been developed for the urinary determination of mutagenic 2,4- and 2,6-toluendiamines. These amines are degradation products of polyurethane, a material used to cover textured silicone breast implants. FMOC-Cl was used as fluorescent derivatising agent in order to obtain a limit of detection of 15 ng/ml in urine. Pre-treatment of urine samples was by liquid/liquid extraction and urine specimens of patients after surgery were analysed.
|Autori:||DeLorenzi E; Massolini G; Macchia M; Caccialanza G|
|Titolo:||HPLC determination of urinary 2,4- and 2,6-toluendiamines as potential degradation products of polyurethane breast implants|
|Anno del prodotto:||1995|
|Digital Object Identifier (DOI):||10.1007/BF02267801|
|Appare nelle tipologie:||1.1 Articolo in rivista|