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EnglishGenetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA–based estimates.
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| Autori: | Francalacci P.; Morelli L.; Angius A.; Berutti R.; Reinier F.; Atzeni R.; Pilu R.; Busonero P.; Maschio A.; Zara I.; Sanna D.; Useli A.; Urru M.F.; Marcelli M.; Cusano R.; Oppo M.; Zoledziewska M.; Pitzalis M.; Deidda F.; Poddie F.; Kang Y.M.; Li B.; Tofanelli S.; Alonso S.; M.Dei; Lai S.; Mulas A.; Whalen M.B.; Uzzau S.; Jones C.; Schlessinger D.; Abecasis G.R.; Sanna S.; Sidore C.; Cucca F. |
| Titolo: | Low pass DNA sequencing of 1,200 Sardinians reconstructs European Y chromosome phylogeny |
| Anno del prodotto: | 2013 |
| Digital Object Identifier (DOI): | 10.1126/science.1237947 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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