BACKGROUND: Obesity is frequently associated with left ventricular hypertrophy (LVH), a condition leading to an increased cardiovascular risk. AIM: The objective of this study was to evaluate the prevalence of LVH in a cohort of obese women, with a main focus on the anthropometric and clinical parameters that are associated with an increased left ventricular mass (LVM). METHODS: The study was performed in 166 obese female patients. LVM was measured by echocardiography. The influence of various parameters on LVM was assessed by multivariate analysis. RESULTS: The prevalence of LVH was drastically different depending on the type of indexed LVM, being 19.9% when the LVM was indexed for body surface area and 72.3% when indexed for height. Age, duration of obesity, weight, waist-to-hip ratio, pulse pressure and hypertension retained an independent direct correlation with the LVM, explaining 39.6% of the overall LVM variability. Among the parameters of the metabolic syndrome, the increase in blood pressure was the main determinant of increased LVM. CONCLUSIONS: By using allometric indexation of LVM for height, the results of our study indicate a high prevalence of LVH in a cohort of obese women. Hypertension, pulse pressure, age, duration of obesity, bodyweight and fat distribution, expressed as waist-to-hip ratio, predict 40% of LVM variation.
|Autori:||Salvetti, G; Pucci, A; Fierabracci, P; Ceccarini, Giovanni; Palagi, C; Delle Donne, Mg; DI BELLO, Vitantonio; Piaggi, P; Vitti, Paolo; Salvetti, A; Pinchera, A; Santini, Ferruccio|
|Titolo:||Prevalence of left ventricular hypertrophy and determinants of left ventricular mass in obese women|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.2165/11593700-000000000-00000|
|Appare nelle tipologie:||1.1 Articolo in rivista|