In order to investigate the ability of infective larvae of the nematode Baylisascaris transfuga (Rudolphi, 1819) Sprent, 1968 to hatch from the egg-shells and then to migrate in tissues, parenteral infections of mice with embryonated eggs were performed. Two groups of outbred albino mice were infected with approximately 3500 B. transfuga infective eggs subcutaneously (SC) or intraperitoneally (IP). B. transfuga larvae in the IP group rapidly hatched and migrated to the intestine, liver, lungs, brain and carcass. Subcutaneous inoculation of eggs was followed also by migration of hatched larvae in the examined organs. In the SC mice, extensive encapsulating reactions involving the subcutaneous tissues and carcass, and containing large numbers of hatched eggs and free motile larvae, were found at the sites of inoculation. Some differences in the migratory behaviour were observed between the two groups. It is shown that B. transfuga infective larvae are able to hatch and migrate in tissues of mice, and tend to settle and/or to be trapped in the intestinal wall and muscles, even after parenteral inoculations of embryonated eggs. These results could provide basic data for further investigations on the migratory pathways of B. transfuga larvae or to perform immunological and therapeutical studies.
PARENTERAL INFECTION IN MICE WITH BAYLISASCARIS-TRANSFUGA (NEMATODA, ASCARIDAE) INFECTIVE EGGS
PAPINI, ROBERTO AMERIGO;
1995-01-01
Abstract
In order to investigate the ability of infective larvae of the nematode Baylisascaris transfuga (Rudolphi, 1819) Sprent, 1968 to hatch from the egg-shells and then to migrate in tissues, parenteral infections of mice with embryonated eggs were performed. Two groups of outbred albino mice were infected with approximately 3500 B. transfuga infective eggs subcutaneously (SC) or intraperitoneally (IP). B. transfuga larvae in the IP group rapidly hatched and migrated to the intestine, liver, lungs, brain and carcass. Subcutaneous inoculation of eggs was followed also by migration of hatched larvae in the examined organs. In the SC mice, extensive encapsulating reactions involving the subcutaneous tissues and carcass, and containing large numbers of hatched eggs and free motile larvae, were found at the sites of inoculation. Some differences in the migratory behaviour were observed between the two groups. It is shown that B. transfuga infective larvae are able to hatch and migrate in tissues of mice, and tend to settle and/or to be trapped in the intestinal wall and muscles, even after parenteral inoculations of embryonated eggs. These results could provide basic data for further investigations on the migratory pathways of B. transfuga larvae or to perform immunological and therapeutical studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
