The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues.
|Autori:||Yoshihara; HAI; Chiellini G; Mitchison TJ; Scanlan TS|
|Titolo:||An efficient substitution reaction for the preparation of thyroid hormone analogues|
|Anno del prodotto:||1998|
|Appare nelle tipologie:||1.1 Articolo in rivista|