We describe a new solid-phase strategy for the selective reduction of the C=N bond in peptide oximes using a trialkylsilane in trifluoroacetic acid. The reduction is performed directly on the resin-bound peptide, with concomitant cleavage of the peptide from the resin and deblocking of protected side chains. © 1996 ESCOM Science Publishers B.V.

Facile reduction of peptide oxime endothelin antagonist during trialkylsilane/TFA cleavage after solid-phase synthesis

MACCHIA, MARCO;
1996-01-01

Abstract

We describe a new solid-phase strategy for the selective reduction of the C=N bond in peptide oximes using a trialkylsilane in trifluoroacetic acid. The reduction is performed directly on the resin-bound peptide, with concomitant cleavage of the peptide from the resin and deblocking of protected side chains. © 1996 ESCOM Science Publishers B.V.
1996
Cassano, E; Macchia, Marco; Hamdan, M; Rovero, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/53912
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