This paper reports the synthesis of 3-substituted-1,2,3-triazolo[1,5-a]quinazolin-5-ones prepared by 1,3-dipolar cycloaddition reaction of 2-azidobenzoic acid to methylenic compounds activated by a cyano group. The new derivatives were submitted to benzodiazepine receptor binding assays: the results indicated an interesting receptorial affinity of the 1,2,3-triazolo[1,5-a]quinazoline ring. On the basis of the biological results, theoretical calculations were performed, which suggested useful structural modifications.
|Autori:||BIAGI G; GIORGI I; LIVI O; SCARTONI V; VELO S; DE SANCTIS B; MARTINELLI A; MARTINI C; SENATORE G.|
|Titolo:||1,2,3-triazolo[1.5-a]quinazolines: synthesis, benzodiazepine receptor binding and theoretical calculations|
|Anno del prodotto:||1996|
|Appare nelle tipologie:||1.1 Articolo in rivista|