Synthesis of Multiply Arylated Heteroarenes, including Bioactive Derivatives, via Palladium-Catalyzed Direct C?H Arylation of Heteroarenes with (Pseudo)Aryl Halides or Aryliodonium Salts

This review with 387 references covers the literature un- til the end of November 2013 on the synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C–H arylation reactions of heteroarene derivatives with aryl halides or pseudohalides or aryliodonium salts. Particular attention has been made to describe the synthesis of biologically active compounds and substances that are privileged structural motifs in organic mate- rials. The practicality, versatility, and limitations of the various de- veloped arylation protocols are discussed.