A variety of 2-substituted 5-alkynyl-1H-imidazoles were easily prepared by a one-pot sequential procedure involving a highly regioselective electrophilic C-5 bromination of 1,2-dimethyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, and 2-aryl-1-methyl-1H-imidazoles, followed by an efficient palladium/ copper co-catalyzed Sonogashira-type alkynylation.
Autori interni: | |
Autori: | Bellina, Fabio; Lessi, Marco; Marianetti, Giulia; Panattoni, Alessandro |
Titolo: | Highly regioselective C-5 alkynylation of imidazoles by one-pot sequential bromination and Sonogashira cross coupling |
Anno del prodotto: | 2015 |
Abstract: | A variety of 2-substituted 5-alkynyl-1H-imidazoles were easily prepared by a one-pot sequential procedure involving a highly regioselective electrophilic C-5 bromination of 1,2-dimethyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, and 2-aryl-1-methyl-1H-imidazoles, followed by an efficient palladium/ copper co-catalyzed Sonogashira-type alkynylation. |
Digital Object Identifier (DOI): | 10.1016/j.tetlet.2015.04.094 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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