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EnglishGlucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.
| Autori interni: | |
| Autori: | Balestri, Francesco; Cappiello, Mario; Moschini, Roberta; Rotondo, Rossella; Abate, Marco; DEL CORSO, Antonella; Mura, Umberto |
| Titolo: | Modulation of aldose reductase activity by aldose hemiacetals |
| Anno del prodotto: | 2015 |
| Abstract: | Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate. |
| Digital Object Identifier (DOI): | 10.1016/j.bbagen.2015.07.007 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| BBA_postprint.pdf | articolo principale | Documento in Post-print | Tutti i diritti riservati (All rights reserved) | Open AccessVisualizza/Apri |
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