Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.

Modulation of aldose reductase activity by aldose hemiacetals

BALESTRI, FRANCESCO;CAPPIELLO, MARIO;MOSCHINI, ROBERTA;ROTONDO, ROSSELLA;ABATE, MARCO;DEL CORSO, ANTONELLA
;
MURA, UMBERTO
2015

Abstract

Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.
Balestri, Francesco; Cappiello, Mario; Moschini, Roberta; Rotondo, Rossella; Abate, Marco; DEL CORSO, Antonella; Mura, Umberto
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/754117
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