Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.
Modulation of aldose reductase activity by aldose hemiacetals
BALESTRI, FRANCESCO;CAPPIELLO, MARIO;MOSCHINI, ROBERTA;ROTONDO, ROSSELLA;ABATE, MARCO;DEL CORSO, ANTONELLA
;MURA, UMBERTO
2015-01-01
Abstract
Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.File in questo prodotto:
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