Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.
Modulation of aldose reductase activity by aldose hemiacetals
BALESTRI, FRANCESCO;CAPPIELLO, MARIO;MOSCHINI, ROBERTA;ROTONDO, ROSSELLA;ABATE, MARCO;DEL CORSO, ANTONELLA
;MURA, UMBERTO
2015
Abstract
Glucose is considered as one of the main sources of cell damage related to aldose reductase (AR) action in hyperglycemic conditions and a worldwide effort is posed in searching for specific inhibitors of the enzyme. This AR substrate has often been reported as generating non-hyperbolic kinetics, mimicking a negative cooperative behavior. This feature was explained by the simultaneous action of two enzyme forms acting on the same substrate.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
BBA_postprint.pdf
accesso aperto
Descrizione: articolo principale
Tipologia:
Documento in Post-print
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
842.74 kB
Formato
Adobe PDF
|
842.74 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
