In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological inheritance but also the clinical concept of ALS. Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.
Amyotrophic Lateral Sclerosis: A Genetic Point Of View
CARLESI, CECILIA;CALDARAZZO IENCO, ELENA;MANCUSO, MICHELANGELO;SICILIANO, GABRIELE
2014-01-01
Abstract
In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological inheritance but also the clinical concept of ALS. Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.File in questo prodotto:
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