Fifty-four canine mammary lesions (15 hyperplasias, 7 adenomas and 32 carcinomas) were submitted to immunohistochemical analysis for the evaluation of PTEN and E-cadherin co-expression. Subjects bearing mammary carcinomas were also submitted to a 2-year follow-up study to compare immunohistochemical results with overall survival All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively. Statistical analysis showed a positive correlation between these two proteins both considering all (p <0.01) or malignant tumours (p <0.05). The female dogs bearing tumours positively-stained for both markers had a longer overall survival (p <0.05) and absence of lymphatics invasion (p <0.05). Simultaneous double immunofluorescence confirmed the co-localization of the two proteins in neoplastic cells. Results reported in this study confirm the tumor suppressor effect of these two molecules.
Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumours
MILLANTA, FRANCESCA;VANNOZZI, IACOPO;POLI, ALESSANDRO
2015-01-01
Abstract
Fifty-four canine mammary lesions (15 hyperplasias, 7 adenomas and 32 carcinomas) were submitted to immunohistochemical analysis for the evaluation of PTEN and E-cadherin co-expression. Subjects bearing mammary carcinomas were also submitted to a 2-year follow-up study to compare immunohistochemical results with overall survival All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively. Statistical analysis showed a positive correlation between these two proteins both considering all (p <0.01) or malignant tumours (p <0.05). The female dogs bearing tumours positively-stained for both markers had a longer overall survival (p <0.05) and absence of lymphatics invasion (p <0.05). Simultaneous double immunofluorescence confirmed the co-localization of the two proteins in neoplastic cells. Results reported in this study confirm the tumor suppressor effect of these two molecules.File | Dimensione | Formato | |
---|---|---|---|
pten pre print.pdf
accesso aperto
Tipologia:
Documento in Pre-print
Licenza:
Creative commons
Dimensione
141.77 kB
Formato
Adobe PDF
|
141.77 kB | Adobe PDF | Visualizza/Apri |
2015 Co-localization of PTEN and ECadh in canine mammary tumours.pdf
solo utenti autorizzati
Tipologia:
Versione finale editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
827.46 kB
Formato
Adobe PDF
|
827.46 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.