It is well known that a negative cooperative behavior displayed by a monomeric enzyme may be associated with the simultaneous presence of two enzymes acting on the same substrate. In this paper, emphasis is given to the effect exerted by a rapid equilibrium between the enzyme forms in leading to a hyperbolic behavior, thus masking the presence of multiple enzyme forms.
Apparent cooperativity and apparent hyperbolic behavior of enzyme mixtures acting on the same substrate
CAPPIELLO, MARIO;BALESTRI, FRANCESCO;MOSCHINI, ROBERTA;DEL CORSO, ANTONELLA;MURA, UMBERTO
2016-01-01
Abstract
It is well known that a negative cooperative behavior displayed by a monomeric enzyme may be associated with the simultaneous presence of two enzymes acting on the same substrate. In this paper, emphasis is given to the effect exerted by a rapid equilibrium between the enzyme forms in leading to a hyperbolic behavior, thus masking the presence of multiple enzyme forms.File in questo prodotto:
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JournalEnzymeInhibitionMedicinalChemistry_2016_postprint2.pdf
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