Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65-89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Maffei, L.;BALDACCI, FILIPPO;BONANNI, ENRICA;BONUCCELLI, UBALDO;BRUNO, ROSA MARIA;CECCHETTI, LUCA;CERAVOLO, ROBERTO;D'ASCANIO, PAOLA;FARAGUNA, UGO;Gargani, L.;GHIADONI, LORENZO;Giorgi, F. S.;IOFRIDA, CATERINA;MAESTRI, MICHELANGELO;MELISSARI, ERIKA MARIA;PALUMBO, SARA;PELLEGRINI, SILVIA;Poli, A.;SCABIA, GAIA;SCALI, MARIA CHIARA;SCELFO, DANILO;SICILIANO, GABRIELE;STEA, FRANCESCO;
2017-01-01

Abstract

Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65-89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
2017
Maffei, L.; Picano, E.; Andreassi, M. G.; Angelucci, A.; Baldacci, Filippo; Baroncelli, L.; Begenisic, T.; Bellinvia, P. F.; Berardi, N.; Biagi, L.; Bonaccorsi, J.; Bonanni, Enrica; Bonuccelli, Ubaldo; Borghini, A.; Braschi, C.; Broccardi, M.; Bruno, ROSA MARIA; Caleo, M.; Carlesi, C.; Carnicelli, L.; Cartoni, G.; Cecchetti, Luca; Cenni, M. C.; Ceravolo, Roberto; Chico, L.; Cintoli, S.; Cioni, G.; Coscia, M.; Costa, M.; D’Angelo, G.; D'Ascanio, Paola; Nes, M. De; Turco, S. Del; Coscio, E. Di; Galante, M. Di; Lascio, N. di; Faita, F.; Falorni, I.; Faraguna, Ugo; Fenu, A.; Fortunato, L.; Franco, R.; Gargani, L.; Gargiulo, R.; Ghiadoni, Lorenzo; Giorgi, F. S.; Iannarella, R.; Iofrida, Caterina; Kusmic, C.; Limongi, F.; Maestri, Michelangelo; Maffei, M.; Maggi, S.; Mainardi, M.; Mammana, L.; Marabotti, A.; Mariotti, V.; Melissari, ERIKA MARIA; Mercuri, A.; Micera, S.; Molinaro, S.; Narducci, R.; Navarra, T.; Noale, M.; Pagni, C.; Palumbo, Sara; Pasquariello, R.; Pellegrini, Silvia; Pietrini, P.; Pizzorusso, T.; Poli, A.; Pratali, L.; Retico, A.; Ricciardi, E.; Rota, G.; Sale, A.; Sbrana, S.; Scabia, Gaia; Scali, MARIA CHIARA; Scelfo, Danilo; Sicari, R.; Siciliano, Gabriele; Stea, Francesco; Taddei, S.; Tognoni, G.; Tonacci, A.; Tosetti, M.; Turchi, S.; Volpi, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/827234
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