The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 105 M-1s-1 and k-1 > 333.3 s-1, respectively. © 2013 American Chemical Society.

Coherent anti-stokes raman scattering microspectroscopic kinetic study of fast hydrogen bond formation in microfluidic devices

CIANCALEONI, GIANLUCA;
2013

Abstract

The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 105 M-1s-1 and k-1 > 333.3 s-1, respectively. © 2013 American Chemical Society.
Oshovsky, Gennady V.; Rago, Gianluca; Day, James P. R.; Soudijn, Maarten L.; Rock, William; Parekh, Sapun H.; Ciancaleoni, Gianluca; Reek, Joost N. H; Bonn, Mischa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/828365
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