The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 105 M-1s-1 and k-1 > 333.3 s-1, respectively. © 2013 American Chemical Society.
Coherent anti-stokes raman scattering microspectroscopic kinetic study of fast hydrogen bond formation in microfluidic devices
CIANCALEONI, GIANLUCA;
2013-01-01
Abstract
The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 105 M-1s-1 and k-1 > 333.3 s-1, respectively. © 2013 American Chemical Society.File in questo prodotto:
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