The addition of small quantities of water to the proline or prolinamide-catalyzed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduce the observed enantioselectivity. © 2008 Elsevier Ltd. All rights reserved.
Water influences the enantioselectivity in the proline or prolinamide-catalyzed aldol addition of acetone to isatins
ANGELICI, GAETANO;
2009-01-01
Abstract
The addition of small quantities of water to the proline or prolinamide-catalyzed aldol addition of acetone to isatin can result in increased enantioselectivity. DFT B3LYP calculations with a water molecule explicitly incorporated in the aldol transition states reproduce the observed enantioselectivity. © 2008 Elsevier Ltd. All rights reserved.File in questo prodotto:
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