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EnglishAims and Background: Radiobiological and technical considerations have traditionally limited the role of radiation therapy in the context of primary and secondary cardiac malignancies. Stereotactic body radiotherapy (SBRT) is a promising modality for the delivery of focused high-dose radiation with ablative potential to complex targets such as small, deep-seated, moving lesions, allowing also for re-irradiation. Methods: Between January 2013 and October 2013, 3 patients underwent SBRT for cardiac lesions: 2 patients had recurrent, previously irradiated cardiac angiosarcomas (PCA) and 1 patient had a cardiac metastasis from melanoma. They were treated with fiducial-guided robotic radiotherapy with CyberKnife. As for dose prescription, 24 Gy in 3 fractions (80% isodose) and 30 Gy in 5 fractions (80% isodose) were administered to the recurrent PCAs and cardiac metastasis, respectively. Results: At 2 months after SBRT, cardiac MRI showed a partial response in the patients treated for recurrent PCA while the cardiac metastasis remained stable. In all cases, absence of local progression was subsequently confirmed by contrast-enhanced cardiac MRI after 6 months, without any evidence of treatment-related side effects. Conclusions: Fiducial-guided SBRT proved to be feasible and effective in preventing local disease progression in selected patients with cardiac malignancies.
Stereotactic body radiotherapy with CyberKnife for cardiac malignancies / Bonomo, Pierluigi; Cipressi, Samantha; Desideri, Isacco; Masi, Laura; Doro, Raffaela; Iermano, Carmine; Greto, Daniela; Simontacchi, Gabriele; Mangoni, Monica; Paiar, Fabiola; Meattini, Icro; Scoccianti, Silvia; Santoro, Gennaro; Valente, Serafina; Gensini, Gian Franco; Livi, Lorenzo. - In: TUMORI. - ISSN 0300-8916. - 101:3(2015), pp. 294-297.
| Autori interni: | ||
| Autori: | Bonomo, Pierluigi; Cipressi, Samantha; Desideri, Isacco; Masi, Laura; Doro, Raffaela; Iermano, Carmine; Greto, Daniela; Simontacchi, Gabriele; Mangoni, Monica; Paiar, Fabiola; Meattini, Icro; Scoccianti, Silvia; Santoro, Gennaro; Valente, Serafina; Gensini, Gian Franco; Livi, Lorenzo | |
| Titolo: | Stereotactic body radiotherapy with CyberKnife for cardiac malignancies | |
| Anno del prodotto: | 2015 | |
| Abstract: | Aims and Background: Radiobiological and technical considerations have traditionally limited the role of radiation therapy in the context of primary and secondary cardiac malignancies. Stereotactic body radiotherapy (SBRT) is a promising modality for the delivery of focused high-dose radiation with ablative potential to complex targets such as small, deep-seated, moving lesions, allowing also for re-irradiation. Methods: Between January 2013 and October 2013, 3 patients underwent SBRT for cardiac lesions: 2 patients had recurrent, previously irradiated cardiac angiosarcomas (PCA) and 1 patient had a cardiac metastasis from melanoma. They were treated with fiducial-guided robotic radiotherapy with CyberKnife. As for dose prescription, 24 Gy in 3 fractions (80% isodose) and 30 Gy in 5 fractions (80% isodose) were administered to the recurrent PCAs and cardiac metastasis, respectively. Results: At 2 months after SBRT, cardiac MRI showed a partial response in the patients treated for recurrent PCA while the cardiac metastasis remained stable. In all cases, absence of local progression was subsequently confirmed by contrast-enhanced cardiac MRI after 6 months, without any evidence of treatment-related side effects. Conclusions: Fiducial-guided SBRT proved to be feasible and effective in preventing local disease progression in selected patients with cardiac malignancies. | |
| Digital Object Identifier (DOI): | 10.5301/tj.5000280 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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