Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might be involved in late-onset Alzheimer's disease (LOAD), but evidence in humans is limited. We assessed the methylation levels of the mtDNA D-loop region in blood DNA from 133 LOAD patients and 130 controls, observing a significant 25% reduction of DNA methylation levels in the first group (2.3 versus 3.1%). Overall, the present data indicate that there is a decreased methylation of the D-loop region in LOAD peripheral blood DNA, suggesting that mtDNA epimutations deserve further investigations in AD pathogenesis.
COPPEDE', FABIO (Ultimo)
|Autori:||Stoccoro, Andrea; Siciliano, Gabriele; Migliore, Lucia; Coppede', Fabio|
|Titolo:||Decreased Methylation of the Mitochondrial D-Loop Region in Late-Onset Alzheimer's Disease|
|Anno del prodotto:||2017|
|Digital Object Identifier (DOI):||10.3233/JAD-170139|
|Appare nelle tipologie:||1.1 Articolo in rivista|