Halophytes are perennial plants very resistant to severe conditions and sustain abiotic stress. Recently there has been an increasing interest for their use as a source of bioactive compounds [1]. Cressa cretica L. (Convolvulaceae) is a widely grown halophytic plant, traditionally used for the treatment of different ailments. Previous investigations reported its biological activity as hepatoprotective, antidiabetic, cytotoxic, anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, antitussive, nootropic, analgesic, and antipyretic [2]. Previous phytochemical studies revealed that this plant is very rich in secondary metabolites, including flavonoids, coumarins, steroids, terpenes, and phenolic acids [3]. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. As results, C. cretica showed writhing inhibition in acetic-acid induced peripheral nociception of 43% and 48% at doses of 50 and 100 mg/kg, respectively. The same doses increased latency time in hot plate model of central analgesia by 66% and 78% compared to control group, respectively. The acute anti-inflammatory effect of the extract was explored in the carrageenan-induced rat hind paw oedema test. The inhibition of paw volume was better than that of the standard drug indomethacin. C. cretica significantly decreased rectal temperature in the rats injected with Brewer’s yeast. Phenolic compounds, including chlorogenic acids and flavonol glycosides, were identified by HPLC-PDA-ESIMS/ MS techniques. In conclusion, C. cretica aqueous extract showed both central and peripheral antinociceptive activities and was effective as an anti-inflammatory and antipyretic, probably due to its polyphenolic content. These findings indicated the medicinal importance of this traditionally used plant as a therapeutic remedy for different aliments.
Anti-inflammatory, antipyretic and antinociceptive effects of a Cressa cretica aqueous extract.
Marinella De Leo;Luisa Pistelli
2017-01-01
Abstract
Halophytes are perennial plants very resistant to severe conditions and sustain abiotic stress. Recently there has been an increasing interest for their use as a source of bioactive compounds [1]. Cressa cretica L. (Convolvulaceae) is a widely grown halophytic plant, traditionally used for the treatment of different ailments. Previous investigations reported its biological activity as hepatoprotective, antidiabetic, cytotoxic, anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, antitussive, nootropic, analgesic, and antipyretic [2]. Previous phytochemical studies revealed that this plant is very rich in secondary metabolites, including flavonoids, coumarins, steroids, terpenes, and phenolic acids [3]. In this study, in vivo antinociceptive, anti-inflammatory, and antipyretic activities of C. cretica aqueous extract whole plant were evaluated. In addition, the total polyphenol content, the total flavonoid content, and the chemical characterization of the extract were performed. As results, C. cretica showed writhing inhibition in acetic-acid induced peripheral nociception of 43% and 48% at doses of 50 and 100 mg/kg, respectively. The same doses increased latency time in hot plate model of central analgesia by 66% and 78% compared to control group, respectively. The acute anti-inflammatory effect of the extract was explored in the carrageenan-induced rat hind paw oedema test. The inhibition of paw volume was better than that of the standard drug indomethacin. C. cretica significantly decreased rectal temperature in the rats injected with Brewer’s yeast. Phenolic compounds, including chlorogenic acids and flavonol glycosides, were identified by HPLC-PDA-ESIMS/ MS techniques. In conclusion, C. cretica aqueous extract showed both central and peripheral antinociceptive activities and was effective as an anti-inflammatory and antipyretic, probably due to its polyphenolic content. These findings indicated the medicinal importance of this traditionally used plant as a therapeutic remedy for different aliments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
