TT virus (TTV) infection is extremely widespread in the general population. A sensitive real-time PCR assay was developed that quantitated accurately the most prevalent TTV genotypes in Italy. When used to test 217 individuals for TTV viraemia, the overall prevalence was 94%. Viraemia levels varied widely amongst individual subjects, with no major differences related to gender or age. The highest TTV titres were in haemophiliacs and in patients with non-A-E hepatitis, but they did not differ from the group with miscellaneous diseases. HIV- and HCV-infected subjects and patients with primary liver diseases had TTV loads similar to those of healthy individuals. (C) 2001 Wiley-Liss, Inc.

TT virus levels in the plasma of infected individuals with different hepatic and extrahepatic pathology

Mauro Pistello
Writing – Review & Editing
;
Fabrizio Maggi
Writing – Original Draft Preparation
;
Giulia Freer
Writing – Original Draft Preparation
;
Santino Marchi
Writing – Original Draft Preparation
;
2001

Abstract

TT virus (TTV) infection is extremely widespread in the general population. A sensitive real-time PCR assay was developed that quantitated accurately the most prevalent TTV genotypes in Italy. When used to test 217 individuals for TTV viraemia, the overall prevalence was 94%. Viraemia levels varied widely amongst individual subjects, with no major differences related to gender or age. The highest TTV titres were in haemophiliacs and in patients with non-A-E hepatitis, but they did not differ from the group with miscellaneous diseases. HIV- and HCV-infected subjects and patients with primary liver diseases had TTV loads similar to those of healthy individuals. (C) 2001 Wiley-Liss, Inc.
Pistello, Mauro; Morrica, Antonietta; Maggi, Fabrizio; Linda Vatteroni, Maria; Freer, Giulia; Fornai, Claudia; Casula, Francesca; Marchi, Santino; Ciccorossi, Pietro; Rovero, Paolo; Bendinelli, Mauro
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/913135
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