Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Facioni, Maria Sole;Ruffoni, Barbara;Tavanti, Arianna;Bertoli, Alessandra;Pistelli, Luisa;Scarpato, Roberto
2018-01-01

Abstract

Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.
Facioni, Maria Sole; Soares, Joana; Adinolfi, Barabara; Gomes, Sara; Raimundo, Liliana; Contini, Adele; Ruffoni, Barbara; Azzarà, Alessia; Tavanti, Arianna; Bertoli, Alessandra; Pistelli, Luisa; Saraiva, Lucilia; Scarpato, Roberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/952939
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