Three-dimensional models for alphaB-crystallin and its complex with zinc were obtained by molecular homology modeling and quantum mechanical calculations in order to explain the effect of the metal on the chaperone-like activity of alphaB-crystallin. In fact, measurements of the chaperone-like activity of alphaB-crystallin revealed that it is significantly increased in presence of the zinc. The theoretical models allowed us to estimate the increased exposition of hydrophobic residues caused by the presence of zinc, suggesting a relationship between structural changes and the increased chaperone-like activity.
|Autori:||ALESSIO COI; BIANUCCI A; MARIA LUISA GANADU; GIOVANNI MARIA MURA|
|Titolo:||A modeling study of alphaB-crystallin in complex with zinc for investigating the correlation between chaperone-like activity and exposure of hydrophobic surfaces|
|Anno del prodotto:||2005|
|Appare nelle tipologie:||1.1 Articolo in rivista|