Aim: This multicenter, retrospective study evaluates the clinical benefit (CB) of bevacizumab, alone or in combination, in recurrent gliomas (RG). Patients & methods: The CB was measured as a reduction of corticosteroid dosage and an improvement ≥20 points in the Karnofsky Performance Status lasting ≥3 months. Results: We collected data of 197 RG patients. A CB was observed in 120, patients without significant differences between patients treated with bevacizumab alone or in combination. The rate of patients who achieved a CB and free from progression at 1 year was 21.5 versus 1.4% in patients who did not report CB. Conclusion: The majority of RG patients treated with bevacizumab reported CB. Moreover, patients with CB showed improved survival.

A multicenter real-world study of bevacizumab in heavily pretreated malignant gliomas: Clinical benefit is a plausible end point?

Pasqualetti F.;Gonnelli A.;Molinari A.;Cantarella M.;Paiar F.;
2019-01-01

Abstract

Aim: This multicenter, retrospective study evaluates the clinical benefit (CB) of bevacizumab, alone or in combination, in recurrent gliomas (RG). Patients & methods: The CB was measured as a reduction of corticosteroid dosage and an improvement ≥20 points in the Karnofsky Performance Status lasting ≥3 months. Results: We collected data of 197 RG patients. A CB was observed in 120, patients without significant differences between patients treated with bevacizumab alone or in combination. The rate of patients who achieved a CB and free from progression at 1 year was 21.5 versus 1.4% in patients who did not report CB. Conclusion: The majority of RG patients treated with bevacizumab reported CB. Moreover, patients with CB showed improved survival.
Villani, V.; Fabi, A.; Tanzilli, A.; Pasqualetti, F.; Lombardi, G.; Vidiri, A.; Gonnelli, A.; Molinari, A.; Cantarella, M.; Bellu, L.; Terrenato, I.; Carosi, M.; Maschio, M.; Telera, S. M.; Carapella, C. M.; Cognetti, F.; Paiar, F.; Zagonel, V.; Pace, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/995128
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