Compds. of formula I [X = CH2, O, S, NH, CO, NHCO, etc.; Y = (CH2)m; m = 0-2; R1-R6 = H, halo, aryl, nitro, (substituted) NH2, SMe, SO2Me, alkyl, heterocyclyl, etc.; M, M1 = O, CH2, CH=CH, CO, NH, S, heterocyclyl, etc.; Q, Q1 = H, acyl, (substituted) NH2, β-lactam, etc.] are prepd. for the treatment and diagnosis of degenerative disorders characterized by high cell proliferation or tissue degeneration. Thus, II was prepd. and had IC50 value of 222 nM against human glioblastoma cells.
COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF
Rossello, Armando;Nuti, Elisa;Orlandini, Elisabetta;Nencetti, Susanna;Martini, Claudia;Costa, Barbara;Giacomelli, Chiara;Daniele, Simona
2018-01-01
Abstract
Compds. of formula I [X = CH2, O, S, NH, CO, NHCO, etc.; Y = (CH2)m; m = 0-2; R1-R6 = H, halo, aryl, nitro, (substituted) NH2, SMe, SO2Me, alkyl, heterocyclyl, etc.; M, M1 = O, CH2, CH=CH, CO, NH, S, heterocyclyl, etc.; Q, Q1 = H, acyl, (substituted) NH2, β-lactam, etc.] are prepd. for the treatment and diagnosis of degenerative disorders characterized by high cell proliferation or tissue degeneration. Thus, II was prepd. and had IC50 value of 222 nM against human glioblastoma cells.File in questo prodotto:
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