Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the in vitro emergence/evolution of resistance against tavaborole in Trichophyton rubrum When T. rubrum strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10-8 The frequency was almost 100-fold higher following fungal growth in the presence of a sub-inhibitory tavaborole concentration (0.5-fold the MIC) for ten transfers. All collected mutants showed similar 4- to 8-fold increase in the drug minimal inhibitory concentration. No cross-resistance to other antifungals was evidenced.

In vitro resistance and evolution of resistance to tavaborole in Trichophyton rubrum

Mazzantini, Diletta
Primo
;
Celandroni, Francesco
Secondo
;
Calvigioni, Marco;Lupetti, Antonella;Ghelardi, Emilia
Ultimo
2021-01-01

Abstract

Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the in vitro emergence/evolution of resistance against tavaborole in Trichophyton rubrum When T. rubrum strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10-8 The frequency was almost 100-fold higher following fungal growth in the presence of a sub-inhibitory tavaborole concentration (0.5-fold the MIC) for ten transfers. All collected mutants showed similar 4- to 8-fold increase in the drug minimal inhibitory concentration. No cross-resistance to other antifungals was evidenced.
2021
Mazzantini, Diletta; Celandroni, Francesco; Calvigioni, Marco; Lupetti, Antonella; Ghelardi, Emilia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1077736
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