Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2-
Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2-
pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin-
1-yl)-amino]propoxybenzaldehyde-O-(substituted)
Benzyl Oximes

Orlandini, Elisabetta; Rapposelli, Simona; Nencetti, Susanna; Giannaccini, Gino; Betti, Laura; Balsamo, A.

doi:10.1002/ardp.200600123

Some oxime ether-substituted aryloxypropanolamines 3-5, structurally related to the active metabolite 2 of sarpogrelate 1, were synthesized and tested for their affinities at 5-HT2A and 5-HT1A serotoninergic receptors as well as at the α1-adrenoceptor. The results show that the compounds possess, at least partially, the ability of the model compounds 1 and 2 to interact with the 5-HT2A-receptors; they have the same selectivity towards 5-HT2A receptors vs α1-adrenoceptors.

Autori interni:	ORLANDINI, ELISABETTA RAPPOSELLI, SIMONA NENCETTI, SUSANNA GIANNACCINI, GINO BETTI, LAURA BALSAMO A. mostra contributor esterni nascondi contributor esterni
Autori:	ORLANDINI E; RAPPOSELLI S; NENCETTI S; GIANNACCINI G; BETTI L; BALSAMO A
Titolo:	Synthesis and 5-HT2A, 5-HT1Aand a1-Binding Affinities of 2-[2- Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-Hydroxy-3-(2- pyridin-2-yl-ethyl)amino]- and 2-[2-Hydroxy-3-(4-N-methylpiperazin- 1-yl)-amino]propoxybenzaldehyde-O-(substituted) Benzyl Oximes
Anno del prodotto:	2007
Digital Object Identifier (DOI):	10.1002/ardp.200600123
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11568/117575

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