Englishendo-3-Amino-exo-2-(3,4-dihydroxyphenyl)-2-hydroxybicyclo[2.2.1]he ptane (4a) and its N-isopropyl derivative (4b) were synthesized and assayed for their adrenergic activity on various isolated preparations. Compounds 4a and 4b, tested up to a dose of 10(-4) M, did not reveal any activity, either stimulant or blocking, on the alpha- and beta-adrenoceptors. Possible rationalizations of the results obtained, however, are suggested.
| Autori: | |
| Autori: | Balsamo A; Breschi MC; Lapucci A; Macchia B; Macchia F; Martinotti E; Nencetti S; Nieri P; Orlandini E |
| Titolo: | SYNTHESIS AND EVALUATION OF THE PHARMACOLOGICAL ACTIVITY OF RIGID ANALOGUES OF SYMPATHOMIMETIC DERIVED FROM BICYCLO[2.2.1]HEPTANE |
| Anno del prodotto: | 1989 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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