Pathogenic germline mutations affecting the RET proto-oncogene underlie the development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were to evaluate the prevalence of germline RET mutations in a large series of MTC, collected over the last 25 years, and to reappraise their clinical significance.
Twenty-Five Years Experience on RET Genetic Screening on Hereditary MTC: An Update on The Prevalence of Germline RET Mutations
Elisei, Rossella;Tacito, Alessia;Ramone, Teresa;Ciampi, Raffaele;Bottici, Valeria;Cappagli, Virginia;Viola, David;Matrone, Antonio;Lorusso, Loredana;Valerio, Laura;Giani, Carlotta;Campopiano, Cristina;Prete, Alessandro;Agate, Laura;Molinaro, Eleonora;Romei, Cristina
2019-01-01
Abstract
Pathogenic germline mutations affecting the RET proto-oncogene underlie the development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were to evaluate the prevalence of germline RET mutations in a large series of MTC, collected over the last 25 years, and to reappraise their clinical significance.File in questo prodotto:
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